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A meta-search on PubMed, the web site of the National Library of Medicine, showed over 1300 studies involving Alpha Lipoic Acid. These studies include both animal and human research and double-blind, placebo controlled clinical trials. Here are some of the major clinical studies done on Alpha Lipoic Acid. In addition, abstracts of Alpha Lipoic Acid Research from the MEDLINE can be read here: Alpha Lipoic Acid Research Bailey, D. M. and B. Davies (2001). "Acute mountain sickness; prophylactic benefits of antioxidant vitamin supplementation at high altitude." High Alt Med Biol 2(1): 21-9. Dietrich, M., G. Block, M. Hudes, J. D. Morrow, E. P. Norkus, M. G. Traber, C. E. Cross and L. Grieb G, [Alpha-lipoic acid inhibits HIV replication]. Med Monatsschr Pharm 1992 Aug;15(8):243-4. (Article in German). Jacob S Streeper RS Fogt DL Hokama JY Tritschler HJ Dietze GJ Henriksen EJ, The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle. Diabetes. 1996 Aug; 45(8): 1024-9 1996 0012-1797 Merin JP Matsuyama M Kira T Baba M Okamoto T, Alpha-lipoic acid blocks HIV-1 LTR-dependent expression of hygromycin resistance in THP-1 stable transformants. FEBS-Lett. 1996 Sep 23; 394(1): 9-13 1996 0014-5793. Murray, Michael, ND, Pizzorno, Joseph, ND. Encyclopedia of Natural Medicine, second ed. Prima Publishing, Rocklin. 1998. Packer (2002). "Antioxidant supplementation decreases lipid peroxidation biomarker F(2)- isoprostanes in plasma of smokers." Cancer Epidemiol Biomarkers Prev 11(1): 7-13. Packer L Tritschler HJ Wessel K, Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free-Radic-Biol-Med. 1997; 22(1-2): 359-78 1997 0891-5849. Patrick, L. (2000). "Nutrients and HIV: part three - N-acetylcysteine, alpha-lipoic acid, L- glutamine, and L-carnitine." Altern Med Rev 5(4): 290-305. Reljanovic, M., G. Reichel, K. Rett, M. Lobisch, K. Schuette, W. Moller, H. J. Tritschler and H. Mehnert (1999). "Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy." Free Radic Res 31(3): 171-9. Roesler, R., J. Quevedo, R. Walz and M. Bianchin (1999). "A randomized, double-blind, placebo-controlled trial of deprenyl and thiotic acid in HIV-associated cognitive impairment." Neurology 52(9): 1920-1. Ruhnau, K. J., H. P. Meissner, J. R. Finn, M. Reljanovic, M. Lobisch, K. Schutte, D. Nehrdich, H. J. Tritschler, H. Mehnert and D. Ziegler (1999). "Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy." Diabet Med 16(12): 1040-3. Sachse, G. and B. Willms (1980). "Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy." Horm Metab Res Suppl 9: 105-7. Strokov, I. A., N. A. Kozlova, V. Mozolevskii Iu, S. P. Miasoedov and N. N. Iakhno (1999). "[The efficacy of the intravenous administration of the trometamol salt of thioctic (alpha-lipoic) acid in diabetic neuropathy]." Zh Nevrol Psikhiatr Im S S Korsakova 99(6): 18-22. Ziegler, D. and F. A. Gries (1997). "Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy." Diabetes 46 Suppl 2: S62-6. Ziegler, D., M. Hanefeld, K. J. Ruhnau, H. P. Meissner, M. Lobisch, K. Schutte and F. A. Gries (1995). "Treatment of symptomatic diabetic peripheral neuropathy with the anti- oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study)." Diabetologia 38(12): 1425-33. Ziegler, D., H. Schatz, F. Conrad, F. A. Gries, H. Ulrich and G. Reichel (1997). "Effects of treatment with the antioxidant alpha-lipoic acid on cardiac autonomic neuropathy in NIDDM patients. A 4-month randomized controlled multicenter trial (DEKAN Study). Deutsche Kardiale Autonome Neuropathie." Diabetes Care 20(3): 369-73. | 
