Chronic Fatigue and Immune System
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    Chronic Fatigue and Immune System

Chronic Fatigue Syndrome CFS is a multi-system disease that affects the central nervous and immune systems and often the musculoskeletal system. In The United Kingdom and Canada the condition is known as myalgic encephalomyelitis, or ME for short. “Myalgic” draws attention to the muscle pain, and encephalomyelitis to the effect the disorder has on the brain and the nerves.

In March 1988 the CDC (U.S. Centers for Disease Control) published in Annals of Internal Medicine a group of signs and symptoms that collectively characterize CFS, as follows:

Major Criteria

  1. New onset of fatigue lasting longer than six months with 50 percent reduction in activity
  2. No other medical or psychiatric conditions that could cause the symptoms

Minor Criteria

Symptoms must begin at or after onset of fatigue

  1. Low-grade fever
  2. Sore throat
  3. Painful lymph nodes
  4. Generalized muscle weakness
  5. Muscle pain
  6. Prolonged fatigue after exercise
  7. Headaches
  8. Joint pain
  9. Sleep disturbance
  10. Neuropsychologic complaints, such as forgetfulness, confusion, difficulty concentrating, depression

  11. Acute onset (over a few hours to a few days)

Physical Criteria

  1. Low-grade fever
  2. Throat inflammation
  3. Palpable or tender lymph nodes

The major criteria for diagnosing CFS are:

  1. The new onset of fatigue that lasts longer than six months and reduces one’s level of activity by 50 percent
  2. The exclusion of other medical or psychiatric conditions that could cause the symptoms. However, to be diagnosed with CFS, the patient also must suffer either 8 of the 11 symptoms on the list of minor criteria or 6 of 11 of these symptoms as well as 2 of 3 from the list of physical criteria.

CFS has sometimes been referred to as the "chronic fatigue immune dysfunction syndrome." A number of studies have found many irregularities of the immune system, although there is no consistent pattern. Some components appear to be over reactive, whereas others appear to be under reactive.

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