To date, there have been no reports of adverse reactions involving MSM and other medications. Although interactions with MSM haven't been reported, it hasn't been well tested to see if drug interactions may occur.

MSM works to reduce pain. Patients who take MSM may find it to be so effective that they are able to reduce or eliminate other pain medications, such as Vioxx, Celebrex, ibuprofen, or other NSAID's.